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Synthesis of ring-halogenated histidines and histamines

✍ Scribed by Rahul Jain; Bianca Avramovitch; Louis A. Cohen

Book ID
104208459
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
733 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

Series of ring-halogenated histidines and histamines have been synthesized horn the suitably protected parent bioimidazoles. The 5-X and 2,5-X*-derivatives are obtained by dii electrophilic halogenation while 2-X derivatives (X= Br and I) are prepared by rcgiospecific electrophilic dehalogenation at C-5.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Ring-H
ChemInform Abstract: Synthesis of Ring-Halogenated Histidines and Histamines.
✍ R. JAIN; B. AVRAMOVITCH; L. A. COHEN πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 29 KB πŸ‘ 2 views

Synthesis of Ring-Halogenated Histidines and Histamines. -Histamines (or the corresponding histidine methyl esters) are halogenated predominantly in 5 position leading to monohalo compounds (III), which may be used for the preparation of mixed dihalo derivatives, such as (IV). 2-Halo derivatives ar

Synthesis of novel ring-substituted hist
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Synthesis of novel 2-cycloall,~vI-L-histidines and 2-cycloall, ylhistamines via radical alkylation with cycloall~ylcarbo~lic acids and sih,er nitrate in the presence of 10% H:SOΒ’ by ammonium persulfate is described. The method is also extended to the synthesis of 1,2-diall~TI-L-histidines and 1,2-di