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Synthesis of novel ring-substituted histidines and histamines

✍ Scribed by Rahul Jain; Louis A. Cohen; Michael M. King

Book ID
104207703
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
583 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

Synthesis of novel 2-cycloall,~vI-L-histidines and 2-cycloall, ylhistamines via radical alkylation with cycloall~ylcarbo~lic acids and sih,er nitrate in the presence of 10% H:SOΒ’ by ammonium persulfate is described. The method is also extended to the synthesis of 1,2-diall~TI-L-histidines and 1,2-dialkylhistamines.

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Synthesis of ring-halogenated histidines
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✍ Rahul Jain; Bianca Avramovitch; Louis A. Cohen πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 733 KB

Series of ring-halogenated histidines and histamines have been synthesized horn the suitably protected parent bioimidazoles. The 5-X and 2,5-X\*-derivatives are obtained by dii electrophilic halogenation while 2-X derivatives (X= Br and I) are prepared by rcgiospecific electrophilic dehalogenation a

ChemInform Abstract: Synthesis of Ring-H
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Synthesis of Ring-Halogenated Histidines and Histamines. -Histamines (or the corresponding histidine methyl esters) are halogenated predominantly in 5 position leading to monohalo compounds (III), which may be used for the preparation of mixed dihalo derivatives, such as (IV). 2-Halo derivatives ar