ChemInform Abstract: Synthesis of Ring-Halogenated Histidines and Histamines.

✍ Scribed by R. JAIN; B. AVRAMOVITCH; L. A. COHEN

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199832251

✦ Synopsis

Synthesis of Ring-Halogenated Histidines and Histamines.

-Histamines (or the corresponding histidine methyl esters) are halogenated predominantly in 5 position leading to monohalo compounds (III), which may be used for the preparation of mixed dihalo derivatives, such as (IV). 2-Halo derivatives are only obtained via dehalogenation of 2-halo-5-bromo or 2-halo-5-iodo compounds.