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Synthesis of racemic erythro 2.3-dimethyl-valeric acid and maximum values of specific rotatory powers of (2R.3S) and (2S.3S) 2.3-dimethyl valeric acids

✍ Scribed by Piero Pino; Renzo Rossi; Pietro Bucci


Publisher
Elsevier Science
Year
1966
Tongue
French
Weight
295 KB
Volume
7
Category
Article
ISSN
0040-4039

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The synthesis of 3-prolinomethionine can be easily achieved in a diastereoselective and enantioselective way via zinc-enolate cyclisation. After transmetallation by CuCN.2LiCI, the zinc--copper derivative was reacted with S-methyl methanesulfonothioate leading in a "one-pot" procedure, to N-(0t-meth