Asymmetric synthesis of (2S,3S)- and (2S
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Philippe Karoyan; GΓ©rard Chassaing
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Article
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1997
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Elsevier Science
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English
β 547 KB
The synthesis of 3-prolinomethionine can be easily achieved in a diastereoselective and enantioselective way via zinc-enolate cyclisation. After transmetallation by CuCN.2LiCI, the zinc--copper derivative was reacted with S-methyl methanesulfonothioate leading in a "one-pot" procedure, to N-(0t-meth