In order to investigate the isotope effect on the enzymatic deamination of amphetamine, deuterio-/-amphetamine, dl sulfate was synthesized by the selective reduction of phenyl-2propanone oxime with lithium aluminum deuteride, followed by resolution of the racemic product. The yield of racemic amphet
Synthesis of racemic amphetamine-d1 and amphetamine-d3
β Scribed by Salem E. Najjar; Martin I. Blake; Matthias C. Lu
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 231 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-2135
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## Abstract The synthesis of (R)β(β)β and (S)β(+)β2βaminoβ1βphenylpropaneβ3,3,3βd~3~ via a modification of a published procedure for the unlabelled compounds is described. The preparation of the (S)enantiomer involved in the first step the reduction of Dβphenylβalanine to (R)β2βaminoβ3βphenylβ1βpro
p-iodo-amphetamine was s y n t h e s i z e d by t h e Sandmeyer r e a c t i o n from i o d i n e and p-NH2-amphetamine, i n which t h e amino a l i p h a t i c group was p r o t e c t e d by a n e a s i l y hydrolysable group : t-butyloxycarbonyl. I o d i n e was o b t a i n e d by o x i d a t i o n