The SAR study of a series of 6-aryloxymethyl-8-aryl substituted quinolines is described. Optimization of the series led to the discovery of compound 26b, a highly potent (IC50=0.6 nM) and selective PDE4D inhibitor with a 75-fold selectivity over the A, B, and C subtypes and over 18,000-fold selectiv
β¦ LIBER β¦
Synthesis of pyrrolo[2,3-d]pyridazinones as potent, subtype selective PDE4 inhibitors
β Scribed by Giovannoni, Maria P.; Cesari, Nicoletta; Graziano, Alessia; Vergelli, Claudia; Biancalani, Claudio; Biagini, Pierfrancesco; Piaz, Vittorio Dal
- Book ID
- 111893659
- Publisher
- Informa plc
- Year
- 2007
- Tongue
- English
- Weight
- 250 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1475-6366
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