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ChemInform Abstract: Synthesis and Evaluation as PDE IV Inhibitors of 4,5-Heterocondensed-6- phenyl-3(2H)-pyridazinones

✍ Scribed by V. DAL PIAZ; M. P. GIOVANNONI; C. CASTELLANA; J. M. PALACIOS; J. BELETA; T. DOMENECH; V. SEGARRA


Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Heterocyclic-Fused
✍ Vittorio Dal Piaz; Maria Paola Giovannoni; Carla Castellana; Jose Maria Palacios πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 29 KB

Heterocyclic-Fused 3(2H)-Pyridazinones as Potent and Selective PDE IV Inhibitors: Further Structure-Activity Relationships and Molecular Modeling Studies. -Among a variety of title compounds the derivatives (III) and (IV) emerged as the most interesting PDE IV inhibitors. Compared with Rolipram (III