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ChemInform Abstract: Synthesis and Evaluation of Polycyclic Pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP Phosphodiesterase Inhibitors.

โœ Scribed by Y. XIA; S. CHACKALAMANNIL; M. CZARNIECKI; H. TSAI; H. VACCARO; R. CLEVEN; J. COOK; A. FAWZI; R. WATKINS; H. ZHANG


Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Biolo
โœ M. X. XIANG; B. C. SUH; Y. S. YOUN; Y. LEE; C. K. RHEE ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 36 KB ๐Ÿ‘ 1 views

## Synthesis and Biological Examination of New Pyrimidine Type Derivatives as Potential Phosphodiesterase(PDE) V Inhibitors. -A number of amide-[cf. (VIII)] and sulfonamide-substituted pyrimidine derivatives [cf. (X)] related to Ono's pyrimidine, an efficient PDE V inhibitor, are synthesized and