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ChemInform Abstract: Synthesis and Biological Examination of New Pyrimidine Type Derivatives as Potential Phosphodiesterase(PDE) V Inhibitors.

✍ Scribed by M. X. XIANG; B. C. SUH; Y. S. YOUN; Y. LEE; C. K. RHEE

Publisher: John Wiley and Sons
Year: 2010
Weight: 36 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199847173

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✦ Synopsis

Synthesis and Biological Examination of New Pyrimidine Type

Derivatives as Potential Phosphodiesterase(PDE) V Inhibitors.

-A number of amide-[cf.

(VIII)] and sulfonamide-substituted pyrimidine derivatives [cf. (X)] related to Ono's pyrimidine, an efficient PDE V inhibitor, are synthesized and evaluated for their pharmacological activities. Several derivatives such as (VIIIc), (Xa) and (Xb) show promising phosphodiesterase inhibition. -(XIANG, M.

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