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ChemInform Abstract: Heterocyclic-Fused 3(2H)-Pyridazinones as Potent and Selective PDE IV Inhibitors: Further Structure—Activity Relationships and Molecular Modeling Studies.

✍ Scribed by Vittorio Dal Piaz; Maria Paola Giovannoni; Carla Castellana; Jose Maria Palacios; Jorge Beleta; Teresa Domenech; Victor Segarra

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Heterocyclic-Fused 3(2H)-Pyridazinones as Potent and Selective PDE IV Inhibitors: Further Structure-Activity Relationships and Molecular Modeling Studies. -Among a variety of title compounds the derivatives (III) and (IV) emerged as the most interesting PDE IV inhibitors. Compared with Rolipram (III) and (IV) also show a remarkably better balance between potency and affinity for the Rolipram binding site, which is believed to be responsible for undesirable side effects. -(DAL PIAZ, VITTORIO;

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