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Synthesis of Pyroglutamic Acid Derivatives via Double Michael Reactions of Alkynones

โœ Scribed by Scansetti, Myriam; Hu, Xiangping; McDermott, Benjamin P.; Lam, Hon Wai


Book ID
120241001
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
125 KB
Volume
9
Category
Article
ISSN
1523-7060

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An enantioselective synthesis of a 6oxygenated atisine derivative 20 is described. The atisine skeleton 18 was stereoselectively constructed by the intramolecular double Michael reaction of the enone ester 16. derived. through the al&hy& 3, from the symmetrical ketone 4. The diterpenoid alkaloids ha