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Synthesis of Pyrimidine-Containing Nucleoside β-(R/S)-Hydroxyphosphonate Analogues

✍ Scribed by Maïa Meurillon; Laurent Chaloin; Christian Périgaud; Suzanne Peyrottes

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
1008 KB
Volume
2011
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

A concise route to nucleoside β‐hydroxyphosphonate analogues is described. The use of a nucleoside β‐ketophosphonate as the key intermediate allowed both the (R) and (S) isomers of β‐hydroxyphosphonate analogues in the pyrimidine series to be accessed. Such derivatives may be considered as stable mimics of 5′‐monophosphate nucleosides and, therefore, could be the starting point for the development of potential therapeutic agents.

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