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Synthesis of (2′S)- and (2′R)-2′-Deoxy-2′-[(2-methoxyethoxy)amino] Pyrimidine Nucleosides and Oligonucleotides

✍ Scribed by Timofei S. Zatsepin; Yulia M. Ivanova; Tatiana S. Oretskaya

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
167 KB
Volume
1
Category
Article
ISSN
1612-1872

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Synthesis of (2′S)- and (2′R)-2′-Deoxy-2
Synthesis of (2′S)- and (2′R)-2′-Deoxy-2′-[(2-methoxyethoxy)amino] Pyrimidine Nucleosides and Oligonucleotides
✍ Timofei S. Zatsepin; Yulia M. Ivanova; Tatiana S. Oretskaya 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 167 KB

## Abstract Syntheses of specified 2′‐modified nucleosides were achieved: __a__) __via__ oximation of the 5′,3′‐blocked 2′‐oxocytidine, followed by reduction, or __b__) by intramolecular nucleophilic addition of 3′‐(2‐methoxyethoxy)carbamate to the 2′‐position with opening of __O__^2^,2′‐anhydrouri

Synthesis of (2′S)-2′-Deoxy-2′-C-methylp
Synthesis of (2′S)-2′-Deoxy-2′-C-methylpurine Nucleosides and Their Phosphoramidites
✍ Gerardo Caballero; Mariana Gallo; Javier M. Montserrat; Adolfo M. Iribarren 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 German ⚖ 154 KB 👁 1 views

We describe the stereoselective synthesis of (2'S)-2'-deoxy-2'-C-methyladenosine ( ) and (2'S)-2'-deoxy-2'-C-methylinosine ( ) as well as their corresponding cyanoethyl phosphoramidites 16 and 19 from 6-O-(2,6dichlorophenyl)inosine as starting material. The methyl group at the 2'-position was introd