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Synthesis and Properties of Oligonucleotide Chimeras Containing 5′-Amino-2′-deoxy-2′-fluoroarabinonucleosides

✍ Scribed by Ekaterina Viazovkina; Kyung-Lyum Min; Annie Galarneau; Masad J. Damha


Publisher
John Wiley and Sons
Year
2004
Weight
59 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract Syntheses of specified 2′‐modified nucleosides were achieved: __a__) __via__ oximation of the 5′,3′‐blocked 2′‐oxocytidine, followed by reduction, or __b__) by intramolecular nucleophilic addition of 3′‐(2‐methoxyethoxy)carbamate to the 2′‐position with opening of __O__^2^,2′‐anhydrouri