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ChemInform Abstract: Synthesis and Biological Properties of a New Series of 5-Substituted-pyrimidine-L-nucleoside Analogues.

✍ Scribed by N. B. WESTWOOD; R. T. WALKER

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Biological Properties of a New Series of 5-Substitutedpyrimidine-L-nucleoside Analogues.

-A series of stable pyrrolidine L-nucleoside analogues incorporating the non-standard nucleobase 5-ethyluracil or (E)-(2-bromovinyl)uracil, e.g. compounds (VI), (VII), and (VIII), are prepared via azidopyrrolidines (III). The silyl ether protected urea derivative derived from amine (IVa) and amide (V) undergoes cyclization to the pyrimidine ring with removal of the protecting group yielding alcohol (VII) as major product. The benzoyl derivative (VIb) is found to be a specific inhibitor of vaccinia virus. -(WESTWOOD, N.

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