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Synthesis of pyrido[2,3-d]pyrimidines via palladium-catalyzed reaction of iodouracil with acetylenes

โœ Scribed by Jong Woo Bae; Seung Hwan Lee; Young Jin Cho; Yeon Joo Jung; Han-June Hwang; Cheol Min Yoon

Book ID
104210605
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
172 KB
Volume
41
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The reactions of iodouracils having a formamidine or acetamidine moiety 1 with various acetylenes 2 in DMF at 120 C using potassium carbonate and a catalytic amount of palladium acetate gave a mixture of pyrido [2,3-d]pyrimidine derivatives in good to high yields. Addition of lithium chloride to the reaction solution resulted in a change of reaction selectivity.

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ChemInform Abstract: Synthesis of Pyrido
ChemInform Abstract: Synthesis of Pyrido[2,3-d]pyrimidines via Palladium-Catalyzed Coupling Reaction Followed by Electrocyclic Reaction.
โœ Kee Yoon Rho; Joong Hyup Kim; Sung Hoon Kim; Cheol Min Yoon ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 1 views

## Synthesis of Pyrido[2, pyrimidines via Palladium-Catalyzed Coupling Reaction Followed by Electrocyclic Reaction. -An efficient synthetic route to the title pyridopyrimidines [cf. (VI), (VIII)/(IX), (XI)/(XII)] via Pd-catalyzed coupling of easily achieved 5-iodo-6aminomethyleneaminouracil (IV