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Synthesis of Pyrido[2,3- d ]pyrimidines via the Reaction of Activated Nitrites with Aminopyrimidines

✍ Scribed by Geies, Ahmed A.


Book ID
127220221
Publisher
Chinese Electronic Periodical Services
Year
1999
Tongue
English
Weight
758 KB
Volume
46
Category
Article
ISSN
0009-4536

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The reactions of iodouracils having a formamidine or acetamidine moiety 1 with various acetylenes 2 in DMF at 120 C using potassium carbonate and a catalytic amount of palladium acetate gave a mixture of pyrido [2,3-d]pyrimidine derivatives in good to high yields. Addition of lithium chloride to the