Synthesis of pyrazolo[1,5-a]pyrimidine linked aminobenzothiazole conjugates as potential anticancer agents
β Scribed by Kamal, Ahmed; Tamboli, Jaki R.; Nayak, V. Lakshma; Adil, S.F.; Vishnuvardhan, M.V.P.S.; Ramakrishna, S.
- Book ID
- 120168490
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 684 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0960-894X
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A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the cha
## Abstract magnified image A novel series of pyrazolo [1,5βa] pyrimidines were synthesized by the condensation of substituted chalcones with 5βamino pyrazole in presence of dimethyl formamide. All the synthesized products were characterized by the spectral analysis. Further, all newly synthesized