Synthesis of pyrazolo [4,3-c] pyridazine and isoxazolo [3,4-d] pyridazine derivatives
โ Scribed by Ikhlass M. Abbass; Mohye A. F. Sharaf; Alia A. El-damaty
- Book ID
- 112976655
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 276 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0253-6269
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๐ SIMILAR VOLUMES
## Abstract Reactions of the pyridazine derivatives **1aโc** with phenyl isothiocyanate followed by heterocyclization with ethyl chloroacetate gave the thiazolidinone derivatives **6aโc**. The reactivity of **6a** towards some chemical reagents was studied. ยฉ 2002 Wiley Periodicals, Inc. Heteroatom
The latter compound reacts regioselectively with some nitrilimines and nitrile oxides to afford the corresponding pyrazole and isoxazole derivatives, respectively. These reaction products react with hydrazine hydrate to give the novel pyrazolo [3,4-d]pyridazine and isoxazolo [3,4-d]pyridazine deriva