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Synthesis of (.+-.)-Pyranonaphthoquinone Derivatives (I), a Cdc25A Phosphatase Inhibitor.

✍ Scribed by Akiko Shimbashi; Yuichi Ishikawa; Shigeru Nishiyama


Publisher
John Wiley and Sons
Year
2004
Weight
59 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract Extracellular signal‐regulated kinase (ERK) plays a central role in regulating cell growth, differentiation, and apoptosis. We previously found that 2‐(2‐mercaptoethanol)‐3‐methyl‐1,4‐napthoquinone or Compound 5 (Cpd 5), is a Cdc25A protein phosphatase inhibitor and causes prolonged, st