Halenaquinone and Xestoquinone Derivatives, Inhibitors of Cdc25B Phosphatase from a Xestospongia sp.
β Scribed by Shugeng Cao; Caleb Foster; Marni Brisson; John S. Lazo; David G. I. Kingston
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 13 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract For Abstract see ChemInform Abstract in Full Text.
We have designed, synthesized and purified a 51 amino acid peptide derived from an essential domain of human cdc25C phosphatase. In vivo, differential phosphorylation of this domain regulates either the induction of mitotic processes, or the checkpoint arrest of eukaryotic cells in response to DNA d
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