Synthesis of Purine and Pyrimidine Nucleosides of Thiopentoses 1
✍ Scribed by Urbas, Branko; Whistler, Roy L.
- Book ID
- 120667358
- Publisher
- American Chemical Society
- Year
- 1966
- Tongue
- English
- Weight
- 608 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-3263
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Some novel dihydroxycyclohexyl pyrimidine and purine carbocyclic nucleosides were prepared and tested for inhibitory activity against Cytomegalovirus and Herpes virus-1 and -2. The pathologies related to viral and/or neoplastic affections are one of the primary causes of death in the world. Natural
## Abstract Free energy perturbation calculations were conducted on the mutations of pyrimidine‐to‐pyrimidine, purine‐to‐purine, purine‐to‐pyrimidine, and pyrimidine‐to‐purine nucleosides. The parameters and technique required for these perturbations is presented. Each of the four nucleosides in DN