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Synthesis of 2-S-dioxo isosteres of purine and pyrimidine nucleosides. II

✍ Scribed by Piedad Fernández-Resa; Manfred Stud


Book ID
112126690
Publisher
Journal of Heterocyclic Chemistry
Year
1982
Tongue
English
Weight
236 KB
Volume
19
Category
Article
ISSN
0022-152X

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The synthesis of 4-amino-7-(8-D-ribofuranosyl)-furoC3.2-dlpyrimidine, a new Cnucleoside analog of adenosine. is described. It involves base-catalyzed cyclization of the 2-(ribofuranosyl)-t-cyan0 ethers 3 to afford the ribosyl-3-amino-2-cyanofurans 4a and 48. followed by a two step conversion into th