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Synthesis of furo[3,2-d]pyrimidine nucleosides: A novel c-nucleoside isostere of adenosine

✍ Scribed by Birendra K. Bhattacharya; Mu-Ill Lim; Brian A. Otter; Robert S. Klein

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
234 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of 4-amino-7-(8-D-ribofuranosyl)-furoC3.2-dlpyrimidine, a new Cnucleoside analog of adenosine. is described. It involves base-catalyzed cyclization of the 2-(ribofuranosyl)-t-cyan0 ethers 3 to afford the ribosyl-3-amino-2-cyanofurans 4a and 48. followed by a two step conversion into the desired furoI3.2-dlpyrimidine system.

πŸ“œ SIMILAR VOLUMES

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