Synthesis and antiviral activity of dihydroxycyclohexyl pyrimidine and purine carbocyclic nucleosides

✍ Scribed by F. Calvani; M. Macchia; A. Rossello; M.R. Gismondo; L. Drago; M.C. Fassina; M. Cisternino; P. Domiano

• Book ID: 103983129
• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 215 KB
• Volume: 5
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(95)00439-z

✦ Synopsis

Some novel dihydroxycyclohexyl pyrimidine and purine carbocyclic nucleosides were prepared and tested for inhibitory activity against Cytomegalovirus and Herpes virus-1 and -2.

The pathologies related to viral and/or neoplastic affections are one of the primary causes of death in the world. Natural nucleosides have been the primary models for the design of the most important antitumoral and/or antiviral antimetabolites 1,2 The difference which these last two classes of compounds exhibit compared with reference molecules concerns both the basic heterocyclic portion and the glucidic one. The broad majority of therapeutic nucleosides contain a glycosidic moiety. It has been found that its substitution with a carbocyclic