5'-O-[N-(Anhacyl w imtxy~yJ)sulfi~noyl]uridines 4a+ 5a-e and 5'4-[N~isopoprl)sulh~yI]~ytibs 7-9 have been 8 -d and testcd againat herpes simplex Virus rype 2. condensation of 2',3'-0-isoproWlide-nv5'4-sulfamoyluridim with the N-hydmxysuccinimide esters of Boc-GIy, Boc-LA4 Boc-D-Ah and Boc-LPhe, gave
Pyrimidine Nucleosides Containing 5-Substituent: Synthesis and Antiviral Activity
β Scribed by Stanislav V. Korkach; Olga A. Valueva; Veronika V. Doubniakova; Vladimir A. Korshun; Alexey V. Ustinov
- Book ID
- 113457531
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 65 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0166-3542
No coin nor oath required. For personal study only.
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Some novel dihydroxycyclohexyl pyrimidine and purine carbocyclic nucleosides were prepared and tested for inhibitory activity against Cytomegalovirus and Herpes virus-1 and -2. The pathologies related to viral and/or neoplastic affections are one of the primary causes of death in the world. Natural
Nucleoside analogues containing a 2-deoxy-l,5-anhydro-D-mannitol and a pyrimidine base moiety were synthesized starting from D-glucose via a nucleophilie opening of an epoxide with the heterocyelic base and an inversion of configuration at the 3'-position. Study of the conformation of these molecule
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