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Synthesis of protected allylic amines via palladium(0)-catalyzed amination of allylic acetates

โœ Scribed by Nilantha S. Sirisoma; Patrick M. Woster

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
188 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Synthesis of potential antiparisitic 5'-aminonucloesides such as 10 could not be accomplished using standard amination procedures. Palladium(0)-catalyzed amination of cyclic allylic acetates with benzylamine or phthalimide gave the corresponding protected amines. This method was then extended to the synthesis of target analogue 10.

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