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Synthesis of polysubstituted thiophenes by a catalytic cyclisation of functionalised episulfides

✍ Scribed by Charles M. Marson; Jonathan Campbell


Book ID
104258119
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
162 KB
Volume
38
Category
Article
ISSN
0040-4039

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The reaction of 3-(benzothiazol-2-yl)-3oxopropanenitrile 1 with active methylene reagents 2a-d and sulfur afforded polysubstituted thiophenes 3a-c . The synthetic potential of the b-enaminonitrile moiety in 3a was explored. The reaction of 3a with active methylene reagents 2a-e afforded thieno [2,3b