Synthesis of Polyprenylated Acylphloroglucinols Using Bridgehead Lithiation: The Total Synthesis of Racemic Clusianone and a Formal Synthesis of Racemic Garsubellin A.
β Scribed by Nadia M. Ahmad; Vincent Rodeschini; Nigel S. Simpkins; Simon E. Ward; Alexander J. Blake
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 17 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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The formal total synthesis of epothilone A is described. The 3 is formed by introduction of the thiazole moiety by a Wittig reaction and subsequent functional group transformation. An key steps in the synthesis of the northern hemisphere are a Z-selective ten-membered ring-closing metathesis reactio