Synthesis of phosphopeptides via global phosphorylation on the solid phase: Resolution of H-phosphonate formation
โ Scribed by John W. Perich
- Book ID
- 110268036
- Publisher
- Springer Netherlands
- Year
- 1998
- Tongue
- English
- Weight
- 78 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1573-3149
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๐ SIMILAR VOLUMES
The seven phosphopeptide derivatives based on the native -NEYTA- sequence of the pp60src protein kinase family, Asn-Glu-Tyr(P)-Ser-Ala, Ala-Glu-Tyr(P)-Ser-Ala, Ala-Ser-Tyr(P)-Ser-Ala, Ala-Ser(P)-Tyr-Ser-Ala, Ala-Thr-Tyr(P)-Ser-Ala, Ala-Thr(P)-Tyr-Ser-Ala and Ala-Ser(P)-Tyr(P)-Ser-Ala, were prepared
A novel method for the efficient synthesis of Tyr(P)-containing peptides is described by the 'phosphite-triester' phosphorylation of the tyrosine residue after its incorporation into the peptide chain. In this approach, the peptide resin is assembled by Fmoc solid-phase peptide synthesis (PyBOP ยฎ co