The synthesis and antibacterial activity of a potentral antibiotic, phenoxyacetyl-(L)-cyclosenne activated by a cyclobutenedione moiety, is described.
Synthesis of phenoxyacetyl-N-sulphonyl cycloserine
โ Scribed by Jack E. Baldwin; Si C. Ng; Andrew J. Pratt
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 146 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The synthesis and biological testing of a non-b-lactam monobactam analogue is described. B-Lactam antibiotics acylate D-alanyl processing enzymes (PBP's) involved in peptidoglycan biosynthesis'. The enhanced acylating ability of penicillins e.g. Penicillin V
๐ SIMILAR VOLUMES
## Abstract A simple pathway for the preparation of Dโcycloserine is presented. The intermediates and Dโcycloserine were characterized by FTโIR, ^1^HโNMR spectra and elemental analysis. DโCycloserine can inhibit the growth of __Mycobacterium tuberculosis__ and can be used as a secondโline drug for
## Abstract For Abstract see ChemInform Abstract in Full Text.