Original and Efficient Synthesis of D-Cycloserine

✍ Scribed by Xiaomeng Li; Xia Meng; Hongdong Duan; Lizhen Wang; Shixiao Wang; Yi Zhang; Dawei Qin

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 86 KB
• Volume: 343
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200900316

✦ Synopsis

Abstract

A simple pathway for the preparation of D‐cycloserine is presented. The intermediates and D‐cycloserine were characterized by FT‐IR, ^1^H‐NMR spectra and elemental analysis. D‐Cycloserine can inhibit the growth of Mycobacterium tuberculosis and can be used as a second‐line drug for the treatment of tuberculosis, especially for the use in developing countries.