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ChemInform Abstract: Synthesis and Biological Activity of Cyclic 1,3-Diazolone (IV) as a D-Cycloserine Mimetic.

โœ Scribed by N.-J. HONG; J.-K. CHANG; J.-W. LIM

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Biolo
ChemInform Abstract: Synthesis and Biological Activity of Cyclic Analogues of MPPG and MCPG as Metabotropic Glutamate Receptor Antagonists.
โœ D. MA; H. TIAN; H. SUN; A. P. KOZIKOWSKI; S. PSHENICHKIN; J. T. WROBLEWSKI ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 32 KB ๐Ÿ‘ 1 views

Synthesis and Biological Activity of Cyclic Analogues of MPPG and MCPG as Metabotropic Glutamate Receptor Antagonists. -The synthesis of the two rigidified phenylglycine analogues (VII) and ( XI) is described. Key step is the application of the Bucherer-Bergs reaction affording the hydantoins (VI)