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ChemInform Abstract: Design, Synthesis, and Biological Activity of Diiminoisoindolines as Complement Component 3a Antagonists.

✍ Scribed by Eugene B. Grant; Deodialsingh Guiadeen; Monica Singer; Dennis Argentieri; Dennis J. Hlasta; Michael Wachter

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
33
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Biolo
ChemInform Abstract: Synthesis and Biological Activity of Cyclic Analogues of MPPG and MCPG as Metabotropic Glutamate Receptor Antagonists.
✍ D. MA; H. TIAN; H. SUN; A. P. KOZIKOWSKI; S. PSHENICHKIN; J. T. WROBLEWSKI πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 32 KB

Synthesis and Biological Activity of Cyclic Analogues of MPPG and MCPG as Metabotropic Glutamate Receptor Antagonists. -The synthesis of the two rigidified phenylglycine analogues (VII) and ( XI) is described. Key step is the application of the Bucherer-Bergs reaction affording the hydantoins (VI)