The synthesis and biological testing of a non-b-lactam monobactam analogue is described. B-Lactam antibiotics acylate D-alanyl processing enzymes (PBP's) involved in peptidoglycan biosynthesis'. The enhanced acylating ability of penicillins e.g. Penicillin V
Synthesis of phenoxyacetyl-N-(hydroxydioxocyclobutenyl)cycloserines
β Scribed by Y. Ueda; L.B. Crast Jr.; A.B. Mikkilineni; R.A. Partyka
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 254 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The synthesis and antibacterial activity of a potentral antibiotic, phenoxyacetyl-(L)-cyclosenne activated by a cyclobutenedione moiety, is described.
π SIMILAR VOLUMES
## Abstract A simple pathway for the preparation of Dβcycloserine is presented. The intermediates and Dβcycloserine were characterized by FTβIR, ^1^HβNMR spectra and elemental analysis. DβCycloserine can inhibit the growth of __Mycobacterium tuberculosis__ and can be used as a secondβline drug for
## Abstract For Abstract see ChemInform Abstract in Full Text.
An efficient methodology for a solid phase synthesis of D-and L-cycloserine derivatives is described. Fmoc-D-cycloserine 4 and its L-enantiomer 5 prepared by a selective amine acylation of bis-silylated parent compounds are immobilized on Sasrin or 2-chlorotrityl linker resins using Mitsunobu-type r