Synthesis of PGB1 analogs by radical chain substitution reaction
β Scribed by Tamura, Rui; Kohno, Masatoshi; Utsunomiya, Sei; Yamawaki, Kunihiko; Azuma, Nagao; Matsumoto, Akira; Ishii, Yasutaka
- Book ID
- 127109945
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 844 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In 1969 ve initiated a progrem to study the application of 1,4 addition reactions to the synthesis of prOSteglEt&inB. Recent publications 192 corroborating saw of our work have prompted us to report the preliminary results of our efforts.
The palladium catalyzed coupling of (S)-E-1 -tributylstannyl-1 -octen-3-01 (3) with 2-(6 carbethoxyhexyl)-3-iodo-2-cyclopenten-I-one gave a 70% yield of the (S)-ethyl ester of PGBI. Coriolic acid was synthesized in 75% yield by coupling 3 with Z-lo-iododecenoic acid, demonstrating the tolerance of t