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Synthesis of peptide amides using Fmoc-based solid-phase procedures on 4-methylbenzhydrylamine resins

✍ Scribed by THOMPSON, PHILIP E. ;KEAH, HOOI H. ;GOMME, PETER T. ;STANTON, PETER G. ;HEARN, MILTON T.W.


Book ID
115099817
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
637 KB
Volume
46
Category
Article
ISSN
0367-8377

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To create a novel amino acid incorporating both acidic and aromatic features, trimethyltin azide was used to synthesize l-4-(tetrazol-5-yl)-phenylalanine (Tpa) and the corresponding d,l racemate by [3+2] cycloadditition of azide to the nitrile group of corresponding 4-cyanophenylalanine analogs. N a