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Synthesis of peptide amides by Fmoc-solid-phase peptide synthesis and acid labile anchor groups

✍ Scribed by STÜBER, WERNER ;KNOLLE, JOCHEN ;BREIPOHL, GERHARD


Book ID
115098897
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
593 KB
Volume
34
Category
Article
ISSN
0367-8377

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✍ Paul Lloyd-Williams; Ahmed Merzouk; François Guibé; Fernando Albericio; Ernest G 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 384 KB

High yklds for the cleavage reaction of Fmoc-protected peptide segments fmn an allylic handle may be obtained using tributyltin hydride in the jmsence of (ph3P)PdQ in a 1:l mixture of DMF/DCM. Altematively tbe cleavage reacdon may be carried out using NMA as nuclecpbile in a 2:2:1 mixture of DMSOfl'