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A new acid-labile anchor group for the solid-phase synthesis of C-terminal peptide amides by the Fmoc method.

✍ Scribed by Peter Sieber

Book ID
108382917
Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
212 KB
Volume
28
Category
Article
ISSN
0040-4039

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A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(t) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off th