Synthesis of pentafluorophenyl, 2,4,5-trichlorophenyl and pentachlorophenyl esters of Fmoc-amino acids using Fmoc-amino acid chlorides as intermediates
β Scribed by Vommina V. Suresh Babu; Kuppanna Ananda; Raveendra I. Mathad
- Publisher
- Springer Netherlands
- Year
- 2000
- Tongue
- English
- Weight
- 276 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1573-3149
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π SIMILAR VOLUMES
The synthesis of peptides containing multiple Aib residues was accomplished using Fmoc-Aib-CI in presence of KOBt. As no additional base was added, the duration of coupling reactions could he extended. Thus, the synthesis of the alamethicin 1-4 fragment, Aib-Pro-Aib-Ala, the emerimicin 2-6 fragment,
Fmoc-(R)-b -HomoAsp(OtBu)-OH was used for the synthesis of both (R) and (S) enantiomers of various Fmoc-protected 3-substituted 1,2,4-oxadiazole-containing b 3 -amino acids. The 1,2,4-oxadiazole heterocycle was formed using sodium acetate, a Fmoc-compatible and efficient catalyst for cyclodehydrati