✦ LIBER ✦
Rapid and efficient synthesis of peptide fragments containing α-aminoisobutyric acid using Fmoc-amino acid chlorides/potassium salt of 1-hydroxybenzotriazole
✍ Scribed by Vommina V. Suresh Babu; Hosahudya N. Gopi
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 161 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The synthesis of peptides containing multiple Aib residues was accomplished using Fmoc-Aib-CI in presence of KOBt. As no additional base was added, the duration of coupling reactions could he extended. Thus, the synthesis of the alamethicin 1-4 fragment, Aib-Pro-Aib-Ala, the emerimicin 2-6 fragment, Aib-Aib-Aib-Val-Gly and the Aib tetramer, Fmoc-(Aib)4-OBzl were accomplished in good yield and purity.