Synthesis of Pederic Acid and Related Model Studies

✍ Scribed by Steffen Breitfelder; Anne C. Schuemacher; Thomas Rölle; Makoto Kikuchi; Reinhard W. Hoffmann

• Book ID: 102257279
• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: German
• Weight: 208 KB
• Volume: 87
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200490110

✦ Synopsis

Abstract

{[2‐(Trimethylsilyl)ethoxy]methyl} (SEM)‐protected pederic acid 16 was prepared by deriving the stereogenic center at C(7) from mannitol and those at C(2) and C(3) (mycalamide numbering) from trans‐2,3‐dimethyloxirane. Routes to pederamides involving a late oxygenation at C(7) were explored.