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Highly Diastereoselective Synthesis of Pederic Acid Derivatives

✍ Scribed by Roush, William R.; Marron, Thomas G.; Pfeifer, Lance A.


Book ID
127040344
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
245 KB
Volume
62
Category
Article
ISSN
0022-3263

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## Abstract {[2‐(Trimethylsilyl)ethoxy]methyl} (SEM)‐protected pederic acid **16** was prepared by deriving the stereogenic center at C(7) from mannitol and those at C(2) and C(3) (mycalamide numbering) from __trans__‐2,3‐dimethyloxirane. Routes to pederamides involving a late oxygenation at C(7) w