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Synthesis of palladium-bidentate complex and its application in Sonogashira and Suzuki coupling reactions

✍ Scribed by Haddad, Boumediene; Villemin, Didier; Belarbi, El-habib

Book ID
121654291
Publisher
Versita
Year
2014
Tongue
English
Weight
195 KB
Volume
68
Category
Article
ISSN
0366-6352

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✦ Synopsis

Abstract

A new palladium-bidentate complex [m-C6H4(CH2ImMe)2(PdCl2)] (III) was prepared in two steps. In the first step, [m-C6H4(CH2ImMeAgCl)2] (II) (Im = imidazole moiety) was obtained by reacting imidazolium salt [m-C6H4(CH2ImMe)2]Cl2 (I) (prepared by quaternisation of Nmethylimidazole with 1,3-bis(chloromethyl)benzene) and Ag2O in CH2Cl2. In the next step, treatment of (II) with Pd(CH3CN)2Cl2 afforded complex III which was evaluated for its catalytic activity for C-C bond-formation reactions by examining the coupling reaction of 3-iodoanisole with phenylacetylene in the Sonogashira reaction. In addition, 3-methoxybiphenyls were obtained with good to excellent yields by Suzuki coupling reactions of 3-iodoanisole with phenylboronic acids or phenylborates salts in the presence of this complex.

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