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Synthesis of P1, P4-di(adenosine 5′-) tetraphosphate by leucyl-tRNA synthetase, coupled with ATP regeneration

✍ Scribed by Senji Kitabatake; Munehiko Dombou; Isao Tomioka; Hiroshi Nakajima


Book ID
115760414
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
311 KB
Volume
146
Category
Article
ISSN
0006-291X

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Synthesis of hybrid bisnucleoside 5′, 5‴
✍ Thomas W. Traut 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 490 KB

Aminoacyl tRNA synthetases, by means of a back reaction, are able to synthesize certain 5', 5"'-P1, P4-bisnucleoside tetraphosphates of biological importance, such as Ap4A. Here it is shown that HisRS and TrpRS (Bacillus stearothermophilus) and AlaRS (E. coli) also synthesize the hybrid compounds Ap