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Mechanism of activation of phenylalanine and synthesis of P1,P4-bis(5'-adenosyl)tetraphosphate by yeast phenylalanyl-tRNA synthetase

โœ Scribed by Harnett, Sara P.; Lowe, Gordon; Tansley, Gaynor


Book ID
127196531
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
825 KB
Volume
24
Category
Article
ISSN
0006-2960

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Synthesis of hybrid bisnucleoside 5โ€ฒ, 5โ€ด
โœ Thomas W. Traut ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer ๐ŸŒ English โš– 490 KB

Aminoacyl tRNA synthetases, by means of a back reaction, are able to synthesize certain 5', 5"'-P1, P4-bisnucleoside tetraphosphates of biological importance, such as Ap4A. Here it is shown that HisRS and TrpRS (Bacillus stearothermophilus) and AlaRS (E. coli) also synthesize the hybrid compounds Ap