Whilst developing a strategy for the solid-phase synthesis of lanthionine-containing peptides, we became aware of some problems with a previously published route for the synthesis of orthogonally-protected lanthionine. We report a structural reassignment of the key iodoalanine intermediate and resul
Synthesis of Orthogonally Protected Lanthionines
β Scribed by Mohd Mustapa, M. Firouz; Harris, Richard; Bulic-Subanovic, Nives; Elliott, Susan L.; Bregant, Sarah; Groussier, Marianne F. A.; Mould, Jessica; Schultz, Darren; Chubb, Nathan A. L.; Gaffney, Piers R. J.; Driscoll, Paul C.; Tabor, Alethea B.
- Book ID
- 120560089
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 152 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The reactivity of electrophiles derived from N-tritylserine, threonine and allothreonine esters toward a selection of nucleophiles was investigated. Best yields from substitution products were obtained with N-trityliodoalanine and soft nucleophiles such as thiols. This strategy was applied to the sy
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