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Synthesis of orthogonally protected lanthionines: a reassessment of the use of alanyl β-cation equivalents

✍ Scribed by M.Firouz Mohd Mustapa; Richard Harris; Jessica Mould; Nathan A.L. Chubb; Darren Schultz; Paul C. Driscoll; Alethea B. Tabor

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 118 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)01981-0

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✦ Synopsis

Whilst developing a strategy for the solid-phase synthesis of lanthionine-containing peptides, we became aware of some problems with a previously published route for the synthesis of orthogonally-protected lanthionine. We report a structural reassignment of the key iodoalanine intermediate and resulting lanthionine derivatives.

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