Synthesis of Optically Active Vicinal Fluorohydrins by Lipase-Catalyzed Deracemization
✍ Scribed by Wölker, Dörthe; Haufe, Günter
- Book ID
- 127035797
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 73 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## Abstract Both enantiomers of the six major kinds of __γ__‐lactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various __rac__‐__N__‐methyl‐4‐hydroxyalkanamides via Grignard reaction and the enantioselective acetylatio
The lipase-catalyzed acetylation of a broad spectrum of configurations of the 2-hydroxy acids 1 were assigned by comparison of the gas-chromatographic data with that of racemic 2-hydroxy acids 1 to their 2-acetoxy acids 2 was shown to proceed with high enantioselectivity. Thus, the literature-known