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Synthesis of optically active medium-sized α-aminolactams via ring-closing metathesis

✍ Scribed by Ken-ichi Fuhshuku; Yasuhisa Asano


Book ID
116909559
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
452 KB
Volume
68
Category
Article
ISSN
0040-4020

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Functionalized and unfunctionalized dienes were synthesized from lactones 7 and 6, respectively, which were subjected to ring-closing metathesis (RCM) using Grubbs' catalysts. These dienes provide a systematic study of the stereochemical requirements for efficient cyclization. Moreover, it has been